{"id":591,"date":"2016-11-01T15:40:25","date_gmt":"2016-11-01T15:40:25","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/brumell\/?page_id=15"},"modified":"2024-02-14T22:04:06","modified_gmt":"2024-02-14T22:04:06","slug":"research","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/brumell\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

Research questions<\/h2><\/div>
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The Brumell Lab studies host-pathogen interactions from both the host and pathogen’s perspectives. We are interested in understanding how the pathogen modifies the host in order to avoid the host’s immune system and to establish a niche in which to survive, and in some cases, thrive. Conversely, we also investigate how the host’s innate immune system responds to these pathogens.<\/p>\n

As pathogens need to manipulate the host, they tend to illuminate novel aspects of human cell biology. This has also opened up unique research directions in the lab including investigations into autophagy, membrane damage and repair, and the characterization of new proteins not directly related to the host-pathogen interface.<\/span><\/p>\n<\/div>

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Research methods<\/h2><\/div>
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The unique interface of pathogens and human cell biology requires the diverse use of biological techniques. This ranges from molecular and microbiology to advanced fluorescence and electron microscopies.<\/p>\n

Our core set of techniques includes:<\/p>\n<\/div>

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