{"id":590,"date":"2016-11-01T15:40:04","date_gmt":"2016-11-01T15:40:04","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/brumell\/?page_id=13"},"modified":"2024-02-14T22:04:29","modified_gmt":"2024-02-14T22:04:29","slug":"publications","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/brumell\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Browse our PubMed<\/a> for a complete list of publications. Below are a few summaries of recent studies conducted in the Brumell lab.<\/p>\n<\/div><\/div><\/div><\/div><\/div>

Global Proximity Interactome of the Human Macroautophagy Pathway<\/a><\/h2><\/div>
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In this publication we use advanced proteomics to examine the autophagy pathway. Our findings reveal many new connections of autophagy to essential cellular pathways. We also identify a new role for members of the OSBPL family of lipid transport proteins in autophagy.<\/p>\n<\/div>

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\"A<\/a><\/span><\/div><\/div><\/div><\/div><\/div>
\"Liver<\/a><\/span><\/div><\/div><\/div>

NOX2 NADPH Oxidase Controls Infection by an Intracellular Bacterial Pathogen through Limiting the Type 1 IFN Response<\/a><\/h2><\/div>
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The NOX2 NADPH oxidase was previously thought to control bacterial infection through the production of reactive oxygen species. In this publication we show that this oxidase control\u00a0Listeria monocytogenes<\/i>\u00a0infection indirectly, through the regulation of an antiviral response.\u00a0<\/span><\/p>\n<\/div>

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Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes<\/a><\/h2><\/div>
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Our cells fight viral infection using a group of proteins that can target specific steps in the viral processes. IFITM3 is one such protein, and plays a key role in protecting us from many viruses, including the flu and COVID-19. In this publication we show that the bacterial pathogen\u00a0Listeria monocytogenes<\/i>\u00a0can take advantage of IFITM3 during its infection of host cells.\u00a0<\/span><\/p>\n<\/div>

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