{"id":264,"date":"2017-03-14T17:03:59","date_gmt":"2017-03-14T21:03:59","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/annie-huang\/?page_id=264"},"modified":"2024-07-11T10:45:31","modified_gmt":"2024-07-11T14:45:31","slug":"publications","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/annie-huang\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]Golbourn B, Ho B, Bondoc A et al “A kinome drug screen identifies multi-TKI synergies and ERBB2 signaling as a therapeutic vulnerability in MYC\/TYR subgroup ATRTs.”<\/a> Neuro Oncol. (2024)<\/p>\n

Ho, B., Arnoldo, A., Zhong, Y. et al<\/em>. \u201cRapid, economical diagnostic classification of ATRT molecular subgroup using NanoString nCounter platform<\/a>\u201d. Neurooncol Adv. (2023)<\/p>\n

Khan, S., Solano-Paez, P., Suwal, T et al<\/em>. Clinical phenotypes and prognostic features of ETMRs (Embryonal Tumor with Multi-layered Rosettes) a new CNS tumor entity: A Rare Brain Tumor Registry study<\/a>. The Lancet Child & Adolescent Health.(2021)<\/p>\n

Liu, A.P.Y., Li, B.K., Pfaff, E.\u00a0et al.<\/i>\u00a0Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study<\/a>.\u00a0Acta Neuropathol<\/i>\u00a0(2021).<\/p>\n

Chung P, et al. Modeling germline mutations in pineoblastoma uncovers lysosome disruption- based therapy.<\/a>\u00a0Nat Commun. 2020 Apr 14;11(1):1825.<\/p>\n

Reddy A,et al. Efficacy of High-Dose Chemotherapy and Three-Dimensional Conformal Radiation for Atypical Teratoid\/Rhabdoid Tumor: A Report From the Children’s Oncology Group Trial ACNS0333<\/a>. J Clin Oncol. 2020 Apr 10;38(11):1175-1185.<\/p>\n

Hoffman LM, Richardson EA, et al. Advancing biology based therapeutic approaches for atypical teratoid rhabdoid tumors<\/a>. Neuro Oncol. 2020 Jul 7;22(7):944-954.<\/p>\n

Ho B, Johann PD, Grabovska Y, et al. Molecular subgrouping of atypical teratoid\/rhabdoid tumors-a reinvestigation and current consensus<\/a>.\u00a0Neuro Oncol<\/i>. 2020;22(5):613-624. doi:10.1093\/neuonc\/noz235<\/p>\n

Li, B.K., Vasiljevic, A., Dufour, C. et al.\u00a0Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study.<\/a>\u00a0Acta Neuropathol<\/i>\u00a0139,\u00a0223\u2013241 (2020). https:\/\/doi.org\/10.1007\/s00401-019-02111-y<\/p>\n

Sin-Chan P, Mumal I, Suwal T, et al. A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.<\/a>\u00a0Cancer Cell<\/i>. 2019;36(1):51-67.e7. doi:10.1016\/j.ccell.2019.06.002<\/p>\n

Lambo S, Gr\u00f6bner SN et al. The molecular landscape of ETMR at diagnosis and relapse<\/a>. Nature. 2019 Dec;576(7786):274-280.<\/p>\n

Torchia J, Golbourn B, Feng S, et al. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors<\/a>.\u00a0Cancer Cell<\/i>. 2016;30(6):891-908. doi:10.1016\/j.ccell.2016.11.003<\/p>\n

Torchia J, Picard D, Lafay-Cousin L, et al. Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis<\/a>.\u00a0Lancet Oncol<\/i>. 2015;16(5):569-582. doi:10.1016\/S1470-2045(15)70114-2<\/p>\n

Spence T, Sin-Chan P, Picard D, et al. CNS-PNETs with C19MC amplification and\/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity<\/a>.\u00a0Acta Neuropathol<\/i>. 2014;128(2):291-303. doi:10.1007\/s00401-014-1291-1<\/p>\n

Kleinman CL, Gerges N, Papillon-Cavanagh S, et al. Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR<\/a>.\u00a0Nat Genet<\/i>. 2014;46(1):39-44. doi:10.1038\/ng.2849<\/p>\n

Spence T, Perotti C, Sin-Chan P, et al. A novel C19MC amplified cell line links Lin28\/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes<\/a>.\u00a0Neuro Oncol<\/i>. 2014;16(1):62-71. doi:10.1093\/neuonc\/not162<\/p>\n

Sin-Chan P, Huang A. DNMTs as potential therapeutic targets in high-risk pediatric embryonal brain tumors.<\/a>\u00a0Expert Opin Ther Targets<\/i>. 2014;18(10):1103-1107. doi:10.1517\/14728222.2014.938052<\/p>\n

Fried I, Huang A, Bartels U, et al. Chronic residual lesions in metastatic medulloblastoma patients.<\/a>\u00a0J Pediatr Hematol Oncol<\/i>. 2014;36(1):71-75. doi:10.1097\/MPH.0b013e3182843b40<\/p>\n

Picard D, Miller S, Hawkins CE, et al. Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis<\/a>.\u00a0Lancet Oncol<\/i>. 2012;13(8):838-848. doi:10.1016\/S1470-2045(12)70257-7<\/p>\n

Zhou L, Picard D, Ra YS, et al. Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma.<\/a>\u00a0Cancer Res<\/i>. 2010;70(20):8199-8210. doi:10.1158\/0008-5472.CAN-09-4562<\/p>\n

Li M, Lee KF, Lu Y, et al. Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors.<\/a> Cancer Cell<\/i>. 2009;16(6):533-546. doi:10.1016\/j.ccr.2009.10.025[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_column_text]Golbourn B, Ho B, Bondoc A et al “A kinome drug screen identifies multi-TKI synergies and ERBB2 signaling as a therapeutic vulnerability in MYC\/TYR subgroup ATRTs.” Neuro Oncol. (2024) Ho, B., Arnoldo, A., Zhong, Y. et al. \u201cRapid, economical diagnostic classification of ATRT molecular subgroup using NanoString nCounter platform\u201d. Neurooncol Adv. (2023) Khan, S., Solano-Paez,…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-264","page","type-page","status-publish","hentry","description-off"],"yoast_head":"\nPublications - Annie Huang Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/annie-huang\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text]Golbourn B, Ho B, Bondoc A et al “A kinome drug screen identifies multi-TKI synergies and ERBB2 signaling as a therapeutic vulnerability in MYC\/TYR subgroup ATRTs.” Neuro Oncol. (2024) Ho, B., Arnoldo, A., Zhong, Y. et al. \u201cRapid, economical diagnostic classification of ATRT molecular subgroup using NanoString nCounter platform\u201d. Neurooncol Adv. 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