How Three Self-Secreted Biofilm Exopolysaccharides of Pseudomonas aeruginosa, Psl, Pel, and Alginate, Can Each Be Exploited for Antibiotic Adjuvant Effects in Cystic Fibrosis Lung Infection

2023 May

Jonathan Chung, Shafinaz Eisha, Subin Park, Amanda J. Morris, Isaac Martin

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Pseudomonas aeruginosa aggregation and Psl expression in sputum is associated with antibiotic eradication failure in children with cystic fibrosis

2022 Dec

Amanda J. Morris, Yvonne C. W. Yau, Subin Park, Shafinaz Eisha, Nancy McDonald, Matthew R. Parsek, P. Lynne Howell, Lucas R. Hoffman, Dao Nguyen, Antonio DiGiandomenico, Ashley M. Rooney, Bryan Coburn, Lucia Grana-Miraglia, Pauline Wang, David S. Guttman, Daniel J. Wozniak & Valerie J. Waters

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Approaches to Targeting Bacterial Biofilms in Cystic Fibrosis Airways

2021 Feb

Martin I, Waters V, Grasemann H

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Evaluation of digital dispense-assisted broth microdilution antimicrobial susceptibility testing for Pseudomonas aeruginosa isolates

2021 Apr

Clark ST, Stapleton PJ, Wang PW, Yau YCW, Waters VJ, Hwang DM, Guttman DS

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The role of Psl in the failure to eradicate Pseudomonas aeruginosa biofilms in children with cystic fibrosis

2021 Aug

Amanda J. Morris, Lindsay Jackson, Yvonne CW Yau, Courtney Reichhardt, Trevor Beaudoin, Stephanie Uwumarenogie, Kevin M. Guttman, P. Lynne Howell, Matthew R. Parsek, Lucas R. Hoffman, Dao Nguyen, Antonio DiGiandomenico, David S. Guttman, Daniel J. Wozniak & Valerie J. Waters

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Isolation of Total RNA from Pseudomonas aeruginosa within Biofilms for Measuring Gene Expression

2021 Sep

Kevin Guttman, Pauline Wang, Lindsay Jackson, Amanda Morris, Yvonne Yau, Valerie Waters

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Quantifying the Effects of Antimicrobials on In vitro Biofilm Architecture using COMSTAT Software

2020 Dec

Morris AJ, Li A, Jackson L, Yau YCW, Waters V

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Ecological Succession of Polymicrobial Communities in the Cystic Fibrosis Airways

2020 Dec

Khanolkar RA, Clark ST, Wang PW, Hwang DM, Yau YCW, Waters VJ, Guttman DS

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Clinical Outcomes Associated with Burkholderia cepacia Complex Infection in Patients with Cystic Fibrosis

2020 Dec

Somayaji R, Yau YCW, Tullis E, LiPuma JJ, Ratjen F, Waters V

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Visualization of Pseudomonas aeruginosa within the Sputum of Cystic Fibrosis Patients

2020 Dec

Jackson L, DePas W, Morris AJ, Guttman K, Yau YCW, Waters V

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Pseudomonas aeruginosa strain sharing in early infection among children with cystic fibrosis

2020 Jun

Stapleton PJ, Izydorcyzk C, Clark S, Blanchard A, Wang PW, Yau Y, Waters V, Guttman DS

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Burkholderia cenocepacia ET12 transmission in adults with cystic fibrosis

2020 Jan

Blanchard AC, Tang L, Tadros M, Muller M, Spilker T, Waters VJ, LiPuma JJ, Tullis E

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Microbiology of Cystic Fibrosis Airway Disease

2019 Dec

Blanchard AC, Waters VJ

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Oral Azithromycin and Response to Pulmonary Exacerbations Treated with Intravenous Tobramycin in Children with Cystic Fibrosis

2019 Jul

Klingel M, Stanojevic S, Tullis E, Ratjen F, Waters V

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Reconciling Antimicrobial Susceptibility Testing and Clinical Response in Antimicrobial Treatment of Chronic Cystic Fibrosis Lung Infections

2019 Oct

Waters VJ, Kidd TJ, Canton R, Ekkelenkamp MB, Johansen HK, LiPuma JJ, Bell SC, Elborn JS, Flume PA, VanDevanter DR, Gilligan P

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Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams

2019 Jan

Clark ST, Sinha U, Zhang Y, Wang PW, Donaldson SL, Coburn B, Waters VJ, Yau YCW, Tullis DE, Guttman DS, Hwang DM

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Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population.

2018 Jul

Middleton MA, Layeghifard M, Klingel M, Stanojevic S, Yau YCW, Zlosnik JEA, Coriati A, Ratjen FA, Tullis ED, Stephenson A, Wilcox P, Freitag A, Chilvers M, McKinney M, Lavoie A, Wang PW, Guttman DS, Waters VJ.

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Chronic Antibiotic Use in Cystic Fibrosis: A Fine Balance.

2018 Jun

Waters V.

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Defining chronic Pseudomonas aeruginosa infection in cystic fibrosis.

2018 May

Waters V, Grimwood K

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Early detection using qPCR of Pseudomonas aeruginosa infection in children with cystic fibrosis undergoing eradication treatment.

2018 Mar

Blanchard AC, Rooney AM, Yau Y, Zhang Y, Stapleton PJ, Horton E, Klingel M, Stanojevic S, Ratjen F, Coburn B, Waters V.

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Staphylococcus aureus interaction with Pseudomonas aeruginosa biofilm enhances tobramycin resistance.

2017 Dec

Beaudoin T, Yau YCW, Stapleton PJ, Gong Y, Wang PW, Guttman DS, Waters V

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MexXY efflux pump overexpression and aminoglycoside resistance in cystic fibrosis isolates of Pseudomonas aeruginosa from chronic infections.

2017 Dec

Singh M, Yau YCW, Wang S, Waters V, Kumar A.

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Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis.

2017 Oct

Waters V, Ratjen F.

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Clinical Outcomes Associated with Achromobacter Species Infection in Patients with Cystic Fibrosis.

2017 Sep

Somayaji R, Stanojevic S, Tullis DE, Stephenson AL, Ratjen F, Waters V.

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Pilot trial of tobramycin inhalation powder in cystic fibrosis patients with chronic Burkholderia cepacia complex infection.

2017 Jul

Waters V, Yau Y, Beaudoin T, Wettlaufer J, Tom SK, McDonald N, Rizvi L, Klingel M, Ratjen F, Tullis E.

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Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis.

2017 Jun

Waters V, Ratjen F.

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Effectiveness of a stepwise Pseudomonas aeruginosa eradication protocol in children with cystic fibrosis.

2017 Feb

Blanchard AC, Horton E, Stanojevic S, Taylor L, Waters V, Ratjen F.

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Effect of pulmonary exacerbations treated with oral antibiotics on clinical outcomes in cystic fibrosis.

2017 Apr

Stanojevic S, McDonald A, Waters V, MacDonald S, Horton E, Tullis E, Ratjen F.

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Longitudinal study of Stenotrophomonas maltophilia antibody levels and outcomes in cystic fibrosis patients.

2017 Jan

Wettlaufer J, Klingel M, Yau Y, Stanojevic S, Tullis E, Ratjen F, Waters V.

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Antibiotic treatment for nontuberculous mycobacteria lung infection in people with cystic fibrosis.

2016 Dec

Waters V, Ratjen F.

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Visualizing the Effects of Sputum on Biofilm Development Using a Chambered Coverglass Model.

2016 Dec

Beaudoin T, Kennedy S, Yau Y, Waters V.

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Special considerations for the treatment of pulmonary exacerbations in children with cystic fibrosis.

2016 Oct

Waters V, Stanojevic S, Ratjen F.

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Antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis.

2016 Jul

Amin R, Waters V.

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Infections With Biofilm Formation: Selection of Antimicrobials and Role of Prolonged Antibiotic Therapy.

2016 Jun

Beaudoin T, Waters V.

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Changes in airway inflammation during pulmonary exacerbations in patients with cystic fibrosis and primary ciliary dyskinesia.

2016 Mar

Ratjen F, Waters V, Klingel M, McDonald N, Dell S, Leahy TR, Yau Y, Grasemann H.

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Effect of High-Dose Antimicrobials on Biofilm Growth of Achromobacter Species Isolated from Cystic Fibrosis Patients.

2016 Jan

Tom SK, Yau YC, Beaudoin T, LiPuma JJ, Waters V.

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Clinafloxacin for Treatment of Burkholderia cenocepacia Infection in a Cystic Fibrosis Patient.

2015 Dec

Balwan A, Nicolau DP, Wungwattana M, Zuckerman JB, Waters V.

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Pulmonary Exacerbations in Children with Cystic Fibrosis.

2015 Nov

Waters V, Ratjen F.

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Prolongation of antibiotic treatment for cystic fibrosis pulmonary exacerbations.

2015 Nov

Waters V, Stanojevic S, Klingel M, Chiang J, Sonneveld N, Kukkar R, Tullis E, Ratjen F.

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Factors associated with response to treatment of pulmonary exacerbations in cystic fibrosis patients.

2015 Nov

Waters VJ, Stanojevic S, Sonneveld N, Klingel M, Grasemann H, Yau YC, Tullis E, Wilcox P, Freitag A, Chilvers M, Ratjen FA.

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Activity of Tobramycin against Cystic Fibrosis Isolates of Burkholderia cepacia Complex Grown as Biofilms.

2015 Oct

Waters V, Stanojevic S, Klingel M, Chiang J, Sonneveld N, Kukkar R, Tullis E, Ratjen F.

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Cystic fibrosis microbiology: Advances in antimicrobial therapy.

2015 Sep

Waters V, Smyth A.

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Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung.

2015 Sep

Diaz Caballero J, Clark ST, Coburn B, Zhang Y, Wang PW, Donaldson SL, Tullis DE, Yau YC, Waters VJ, Hwang DM, Guttman DS.

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Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis

2015 Jun

Clark ST, Diaz Caballero J, Cheang M, Coburn B, Wang PW, Donaldson SL, Zhang Y, Liu M, Keshavjee S, Yau YC, Waters VJ, Elizabeth Tullis D, Guttman DS, Hwang DM.

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Lung microbiota across age and disease stage in cystic fibrosis.

2015 May

Coburn B, Wang PW, Diaz Caballero J, Clark ST, Brahma V, Donaldson S, Zhang Y, Surendra A, Gong Y, Elizabeth Tullis D, Yau YC, Waters VJ, Hwang DM, Guttman DS.

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Randomized controlled trial of biofilm antimicrobial susceptibility testing in cystic fibrosis patients.

2015 Mar

Yau YC, Ratjen F, Tullis E, Wilcox P, Freitag A, Chilvers M, Grasemann H, Zlosnik J, Speert D, Corey M, Stanojevic S, Matukas L, Leahy TR, Shih S, Waters V.

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In vitro efficacy of high-dose tobramycin against Burkholderia cepacia complex and Stenotrophomonas maltophilia isolates from cystic fibrosis patients.

2015 Jan

Ratjen A, Yau Y, Wettlaufer J, Matukas L, Zlosnik JE, Speert DP, LiPuma JJ, Tullis E, Waters V.

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