As new genomic screening and diagnostic technologies emerge in prenatal, newborn, and paediatric medicine, there becomes a need to evaluate the impact of these technologies on clinical care decisions, patient experience, and healthcare systems. In partnership with laboratory, clinical, and evaluation scientists, GENOMETRICS uses a range of health services and policy research methods to study the impact of these technologies to provide decision-makers with robust evidence for policy and funding decisions. Our work also aims to build sustainable and equitable models of care that optimize access and ensure appropriate use for a growing number of families eligible for genomic testing.